Example NONMEM Analysis-Ready Dataset for PK Modeling of a Single Ascending Dose Study
Source:R/data_sad_nca.R
data_sad.RdExample NONMEM Analysis-Ready Dataset for PK Modeling of a Single Ascending Dose Study
Format
data.frame a data frame with 720 rows and 23 columns:
- LINE
Line number
- ID
NONMEM subject identifier
- TIME
Actual time since first dose (units: hours)
- NTIME
Nominal time since first dose (units: hours)
- NDAY
Nominal study day (units: days)
- DOSE
Nominal dose assignment (units: mg)
- AMT
Actual dose amount administrered (units: mg)
- EVID
NONMEM-specific event identifier
- ODV
Dependent variable in original units (units: ng/mL)
- LDV
Log-transformed dependent variable (units: log(ng/mL))
- CMT
NONMEM-specific compartment variable (values: 1=dose, 2=plasma concentration)
- MDV
NONMEM-specific missing dependent variable indicator
- BLQ
Concentration below the lower limit of quantification flag (values: -1=pre-dose BLQ, 0=not BLQ, 1=post-dose BLQ)
- LLOQ
Lower limit of quantification (units: ng/mL)
- FOOD
Co-administration with food (values: 0=fasted, 1=high-fat meal)
- SEXF
Subject of female sex (values: 0=male, 1=female)
- RACE
Subject race (units: hours)
- AGEBL
Subject age at baseline (units: years)
- WTBL
Subject body weight at baseline (units:kg)
- SCRBL
Subject serum creatinine at baseline (units: g/dL)
- CRCLBL
Subject creatinine clearance at baseline (units: mL/min)
- USUBJID
Study subject identifier
- PART
Study part
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